Supernova (SN) 2023ixf was discovered on 2023 May 19. The host galaxy, M101, was observed by the Hobby–Eberly Telescope Dark Energy Experiment collaboration over the period 2020 April 30–2020 July 10, using the Visible Integral-field Replicable Unit Spectrograph (3470 ≲
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Abstract λ ≲ 5540 Å) on the 10 m Hobby–Eberly Telescope. The fiber filling factor within ±30″ of SN 2023ixf is 80% with a spatial resolution of 1″. Ther < 5.″5 surroundings are 100% covered. This allows us to analyze the spatially resolved preexplosion local environments of SN 2023ixf with nebular emission lines. The two-dimensional maps of the extinction and the star formation rate (SFR) surface density (ΣSFR) show weak increasing trends in the radial distributions within ther < 5.″5 regions, suggesting lower values of extinction and SFR in the vicinity of the progenitor of SN 2023ixf. The median extinction and that of the surface density of SFR withinr < 3″ areE (B −V ) = 0.06 ± 0.14, andR 23calculations indicates that the gas metallicity around SN 2023ixf is similar to the solar metallicity (∼Z ☉). The archival deep images from the Canada–France–Hawaii Telescope Legacy Survey (CFHTLS) show a clear detection of the progenitor of SN 2023ixf in thez band at 22.778 ± 0.063 mag, but nondetections in the remaining four bands of CFHTLS (u ,g ,r ,i ). The results suggest a massive progenitor of ≈22M ☉. -
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1 + cells contribute to the development of meniscus horns from 2 weeks of age. In adult mice, Gli1 + cells resided at the superficial layer of meniscus and expressed known mesenchymal progenitor markers. In culture, meniscal Gli1 + cells possessed high progenitor activities under the control of Hh signal. Meniscus injury at the anterior horn induced a quick expansion of Gli1-lineage cells. Normally, meniscal tissue healed slowly, leading to cartilage degeneration. Ablation of Gli1 + cells further hindered this repair process. Strikingly, intra-articular injection of Gli1 + meniscal cells or an Hh agonist right after injury accelerated the bridging of the interrupted ends and attenuated signs of osteoarthritis. Taken together, our work identified a novel progenitor population in meniscus and proposes a new treatment for repairing injured meniscus and preventing osteoarthritis.more » « less
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Abstract Background Entinostat is an oral small molecule inhibitor of class I histone deacetylases (HDAC), which has not previously been evaluated in pediatrics. We conducted a phase I trial to determine the maximum tolerated dose/recommended phase 2 dose (MTD/RP2D), toxicity profile, pharmacokinetics (PK), and pharmacodynamics (PD) of entinostat in children with relapsed or refractory solid tumors including central nervous system (CNS) malignancies.
Methods A rolling six dose escalation design evaluated two dose levels. Entinostat oral tablet formulation was administered once per week, four doses per 28‐day cycle. PK and PD studies were performed.
Results Twenty‐one eligible patients’ median (range) age was 14 years (6‐20). Six subjects were treated at 3 mg/m2dose level and 15 were treated in 4 mg/m2dose level. The study included patients with CNS tumors (n = 12), sarcomas (n = 6), or other solid tumors (n = 3). Eight patients were not fully evaluable for toxicity due to progression of disease prior to receiving the required percentage of protocol therapy. No cycle one dose‐limiting toxicity (DLT) was observed at either dose level. A three‐fold higher area under the curve (AUC) was achieved in our cohort compared to adults using a similar dosing schedule. The PD studies showed increase in acetylated lysine in peripheral blood leukocytes at both doses.
Conclusions Entinostat was well tolerated with no DLT observed. All patients experienced progression within the first two cycles, except one patient with ependymoma with stable disease. Based on PK and PD, the R2PD in pediatric patients with solid tumors is 4 mg/m2orally administered once weekly.
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Background Premature restriction or closure of foramen ovale (
FO ) in otherwise structurally normal hearts may be associated with right ventricular dilation, tricuspid regurgitation, pericardial effusion, heart failure, even poor perinatal outcomes. Data about these rare conditions are lacking.Methods We retrospectively reviewed the echocardiographic records of 9704 fetuses seen from 2010 to 2014 in Beijing Anzhen Hospital, a regional and national referral center, to ascertain the presence of restriction or closure of
FO . We collected the fetal echocardiography and perinatal outcome data for this group of fetuses with restriction or closure ofFO .Results In this large, single‐institution cohort (n = 9704), 6707 fetuses seen between 23 and 37 weeks of gestation had normal heart structures; of these, 60 (0.89%) had restrictive
FO (rFO ) and 5 (0.07%) had closure ofFO (cFO ). Fetal echocardiographic images showed right atrial dilation in 48 (73.84%), right ventricular dilation in 38 (58.46%), tricuspid regurgitation in 19 (29.23%), and pericardial effusion in 10 (15.38%). Also in this group, 50 (83.3%) withrFO and 4 (80.0%) withcFO had follow‐up data. No prenatal deaths occurred in either therFO or thecFO group, but the neonatal mortality included 1 in therFO group and 2 in thecFO group.Conclusion Premature
rFO /cFO are rare in fetuses with otherwise structurally normal hearts. The fetal echocardiographic characteristics include right atrial and ventricular dilated, tricuspid regurgitation, and pericardial effusion. Most fetuses had a good outcome, although there was an association betweenrFO , especiallycFO , with neonatal morality and complications (prematurity, maternal preeclampsia and placental abruption, hydrops fetalis, and necrotizing enterocolitis with perforation). -
Abstract JUNO is a multi-purpose neutrino observatory under construction in the south of China. This publication presents new sensitivity estimates for the measurement of the , , , and oscillation parameters using reactor antineutrinos, which is one of the primary physics goals of the experiment. The sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site, the nuclear reactors in the surrounding area and beyond, the detector response uncertainties, and the reactor antineutrino spectral shape constraints expected from the TAO satellite detector. It is found that the and oscillation parameters will be determined to 0.5% precision or better in six years of data collection. In the same period, the parameter will be determined to about % precision for each mass ordering hypothesis. The new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.more » « less
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Abstract Main goal of the JUNO experiment is to determine the neutrino mass ordering using a 20 kt liquid-scintillator detector. Its key feature is an excellent energy resolution of at least 3% at 1 MeV, for which its instruments need to meet a certain quality and thus have to be fully characterized. More than 20,000 20-inch PMTs have been received and assessed by JUNO after a detailed testing program which began in 2017 and elapsed for about four years. Based on this mass characterization and a set of specific requirements, a good quality of all accepted PMTs could be ascertained. This paper presents the performed testing procedure with the designed testing systems as well as the statistical characteristics of all 20-inch PMTs intended to be used in the JUNO experiment, covering more than fifteen performance parameters including the photocathode uniformity. This constitutes the largest sample of 20-inch PMTs ever produced and studied in detail to date, i.e. 15,000 of the newly developed 20-inch MCP-PMTs from Northern Night Vision Technology Co. (NNVT) and 5000 of dynode PMTs from Hamamatsu Photonics K. K.(HPK).more » « less
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Abstract We present the detection potential for the diffuse supernova neutrino background (DSNB) at the Jiangmen Underground Neutrino Observatory (JUNO), using the inverse-beta-decay (IBD) detection channel on free protons. We employ the latest information on the DSNB flux predictions, and investigate in detail the background and its reduction for the DSNB search at JUNO. The atmospheric neutrino induced neutral current (NC) background turns out to be the most critical background, whose uncertainty is carefully evaluated from both the spread of model predictions and an envisaged in situ measurement. We also make a careful study on the background suppression with the pulse shape discrimination (PSD) and triple coincidence (TC) cuts. With latest DSNB signal predictions, more realistic background evaluation and PSD efficiency optimization, and additional TC cut, JUNO can reach the significance of 3σ for 3 years of data taking, and achieve better than 5σ after 10 years for a reference DSNB model. In the pessimistic scenario of non-observation, JUNO would strongly improve the limits and exclude a significant region of the model parameter space.more » « less
